Summary CLINICOPATHOLOGY OF ACUTE CHILDHOOD LYMPHOID LEUKEMIA AND NON-HODGKIN’S LYMPHOMA
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Environmental Risk Factors for Acute Leukemia and Non-Hodgkin Lymphoma in Children
Abstract Objective The incidence of childhood cancer has been increasing nearly one percent per year for the past two decades. Leukemia and lymphoma are the most common types of childhood cancers. This study assessed the relation between environmental factors (Hydrocarbon, agricultural toxin, insecticide) and leukemia/lymphoma in children, which was evaluated by the frequency of the parents...
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Objective(s): Non- Hodgkin lymphoma (NHL) and acute lymphoblastic leukemia (ALL) are two main hematological malignances which have been driven from lymphoid tissue. Genetic polymorphisms in tumor necrosis factor-α (TNF-α) -308 and lymphotoxin-α (LT-α) +252 may affect their transcription and expression which leads to their high plasma level. The frequency of the TNF-α (-308) and LT-...
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Detailed immunophenotypic analyses of immunologically classified leukemias and lymphomas showed that CD40 displays an exquisite 6-lineage specificity within the human lymphopoietic system. Notably, 82% of B-lineage chronic lymphocytic leukemias (CLLs), 82% of B-lineage hairy cell leukemias (HCLs), 86% of B-lineage non-Hodgkin’s lymphomas (NHLs), and 29% of B-lineage acute lymphoblastic leukemia...
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Non-Hodgkin’s Lymphomas are tumors of lymphoid origin with the exception of Hodgkin’s Lymphoma and lymphoid leukemias. This includes a broad spectrum of malignant lymphomas with differing natural histories and prognoses. There have been several attempts to classify these diseases, but none satisfactory. As a result, there are several classifications in use. Therefore, Non-Hodgkin’s Lymphomas (N...
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T National Cancer Institute estimates that 10.1 million Americans have a history of cancer, and that three of every four American families will have at least one family member diagnosed with the disease (National Cancer Institute, 2006). Stem cell transplantation (SCT) has been used for over 50 years (Kolb, Gidwani, & Grupp, 2006) to treat a multitude of cancers and non-myelodysplastic diseases...
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